个人简介
Dr. Yiqian Wu is an Assistant Professor at the National Biomedical Imaging Center, Peking University. She obtained her Ph.D. in Bioengineering from the University of California, San Diego (UCSD), where she later served as a postdoctoral researcher and Assistant Project Scientist before joining Peking University.
Dr. Wu's research lies at the intersection of synthetic biology, sonogenetics, cell therapy, and gene editing. Her group develops next-generation CAR-T cell engineering strategies, synthetic immune circuits, and spatiotemporally controllable therapeutic platforms, including ultrasound-responsive CAR-T immunotherapies and gene-editing systems, to improve the precision, safety, and efficacy of cancer treatment.
Dr. Wu has authored publications in leading journals, including Nature Biomedical Engineering, Nature Communications, and Science Advances. Her pioneering studies on focused ultrasound-controllable CAR-T cells, ultrasound-regulated genomic toolboxes, and light-controllable CAR-T cell therapies have contributed to advancing the emerging fields of sonogenetics and programmable cancer immunotherapy.
代表性论文
1. Huang Z, Wang X, Lin L, Liu Y, Huang X, Zheng P, Liu B, Wu Y. AI-driven cellular immunotherapy: transforming CAR-T engineering and translation. Physics of Life Reviews 58, 113–130. 2026.
2. Wu Y*†, Huang Z*, Liu Y* et al. Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy. Nature Communications. 15, 10444. 2024. *Co-first authors. †Co-corresponding authors.
3. Yan L, Gao S, Wang X, Zhou X, Limsakul P, Wu Y. Boosting CAR-T cell therapy with CRISPR technology. hLife. 2(8):380. 2024.
4. Wu Y, Liu Y, Huang Z, Wang X, Jin Z, Li J, Limsakul P, Zhu L, Allen M, Pan Y, Bussell R, Jacobson A, Liu T, Chien S, Wang Y. Control of the activity of CAR-T cells within tumours via focused ultrasound. Nature Biomedical Engineering. 5, 1336–1347. 2021. (Cover)
5. Huang Z*, Wu Y*, Allen ME, Pan Y, Kyriakakis P, Lu S, Chang YJ, Wang X, Chien S, Wang Y. Engineering light-controllable CAR T cells for cancer immunotherapy. Science Advances. 6 (8): eaay9209. 2020. *Co-first authors.
6. Wu Y and Wang Y. Synthetic Biology: Protein Circuits Reprogram Cells. Nature Chemical Biology. 15(2):96-97. 2019.
